• Basic knowledge in immunology (e.g. through Bachelor course MBT of LSE)

• Previous courses on bioprocess engineering and genetic engineering
  

• Immune system revision: immune reaction, cellular and humoral adaptive and innate immune defence system

• Process pipelines for antibody (AB) production: polyclonal, monoclo-nal, recombinant Abs, biosystems and bioreactor

• Downstream processing of Abs

• Diagnostic and therapeutic AB formulations

• Vaccine Technologies

• Genetic immune modulation technologies Crspr/Cas9

• Manipulation of immune cells and host immune mediators for targeted therapies in Personalized Medicine, e.g. in cancer, HIV, auto-immune disease, malaria, leukaemia

• Organ transplantation: organ rejection through immune incompatibili-ties, immune-suppression, biotechnology strategies

• Recombinant production of immune-modulatory signaling molecules

• New trends in diagnostic immune-technologies (e.g. label-free point-of-care systems, blood analyser, etc.)

• Nano-immuno-technology

Educational objectives and skills:
Students shall

• learn and understand the concepts of innate versus adaptive immune reaction

• comprehend ways to manipulate immune system reaction through humoral and cellular means

• embrace the relationship between genetic diversity and immunological compatibility and be able to depict strategies for genetic manipulation to enforce such compatibility

• be able to understand the concept of Personalized Medicine in designing tailored immune-strategies for selected diseases and name strategies to target immune cells, cancer cells and pathogens

• be able to critically evaluate the technological advances over the individual benefits and risks associated with immune biotechnology approaches

• Literature recommendations will be available through the lecture slide references

• Since the field is a young an actively developing field, there are not many text-books available!

• Anadurai D (2010) A textbook of Immunology & Immunotechnology. S Chand & Co Ltd. ISBN-13: 978-8121928076