Molecular synthesis (MSM-ME1)15 ECTS
(englische Bezeichnung: Molecular synthesis)
(Prüfungsordnungsmodul: Wahlpflichtmodul Molecular Science)

Lehrveranstaltungen:

• Check for other alternatives in UnivIS
  NB: no overlap with courses in Mandatory Module allowed

• A. LAB course Molecular Synthesis

  either in Inorganic or Organic Chemistry (6LAB/1S)
  (Attendance in lab course is compulsory!)

  • Praktikum Anorganische Molekülsynthesen - Masterstudium / Lab Course Molecular Synthesis IC - Master-level program (WS 2017/2018)
    (Praktikum, Karsten Meyer et al., The mandatory orientation session will be at 16/10/2017 (16:15-17:00) in the Lecture Hall H3;. registration and contact: Dr. A. Zahl)
  • Advanced Inorganic Chemistry - Seminar Talk (Vortragsseminar zum Fortgeschrittenenpraktikum Anorganische Chemie ) (WS 2017/2018)
    (Seminar, 1 SWS, Andreas Scheurer)
  • Advanced Inorganic Chemistry - Practical (SS 2018)
    (Praktikum, 8 SWS, Die Dozenten der Anorg. Chemie, Ort und Zeit nach Vereinbarung; Kontakt: Dr. A. Zahl, Vertretung ggfs. Dr. C. Dücker-Benfer)
  • Advanced Inorganic Chemistry - Seminar Talk (Vortragsseminar zum Fortgeschrittenenpraktikum Anorganische Chemie ) (SS 2018)
    (Seminar, 1 SWS, Andreas Scheurer)
  • Praktikum Organische Molekülsynthesen - Masterstudium / Lab Course Molecular Synthesis OC - Master-level program (WS 2017/2018)
    (Praktikum, 7 SWS, Svetlana Tsogoeva et al., Chemikum: 19.02. - 28.03.2018; further information in the introduction and safety instruction session (attendance compulsory!); Vorbesprechung: 9.2.2018, 10:15 - 12:00 Uhr, C3 - Chemikum)
  • Syntheseprobleme in der Organischen Chemie / Synthesis problems in organic chemistry (WS 2017/2018)
    (Seminar, 2 SWS, Andreas Hirsch et al., Mi, 16:15 - 17:45, C3 - Chemikum; first week in gr, HS; attendance compulsory)
  • Advanced Organic Chemistry - Practical (SS 2018)
    (Praktikum, 7 SWS, Andreas Hirsch, usually offered in the winter term)
• Lectures & Seminars:
• B. Advanced Inorganic Chemistry I (2L/1S)
  • Advanced Inorganic Chemistry (WS 2017/2018)
    (Vorlesung, 2 SWS, Ivana Ivanovic-Burmazovic et al., Mi, 13:15 - 14:45, H3 Egerlandstr.3)
  • Advanced Inorganic Chemistry - Seminar (WS 2017/2018)
    (Seminar, 1 SWS, Ivana Ivanovic-Burmazovic et al., Fr, 13:15 - 14:00, H2 Egerlandstr.3)
• C. Advanced Inorganic Chemistry II (1L)

  choice of 1 course from
  C1: Bioinorganic chemistry I (1L)
  C2: Metals in medicine (1L)
  C3: Nanoparticles and nanostructured thin films (1L)
  C4: Modern X-Ray structure determination of single crystals (2L)

  • Bioinorganic Chemistry I, Metalloenzymes and Metals in Medicine (WS 2017/2018)
    (Vorlesung, 2 SWS, Nicolai Burzlaff, Di, 10:15 - 11:45, A00.14)
  • Seminar zur Vorlesung 'Metalle in der Medizin' (WS 2017/2018)
    (Seminar, 1 SWS, Nicolai Burzlaff, Mi, 13:15 - 14:00, A00.14)
  • Nanoparticles and Nanostructured Thin Films / Nanopartikel und nanostrukturierte dünne Schichten (WS 2017/2018)
    (Vorlesung, 2 SWS, Julien Bachmann, Mo, 12:15 - 14:00, H2 Egerlandstr.3; ab 23.10.2017; Institut für Anorganische Chemie, Egerlandstraße 1; starts 2nd week of the term; Seminar: time and place by agreement!)
  • Modern X-ray structure determination of single crystals/Einführung i. d. Kristallstrukturbestimmung von Molekülverbindungen (WS 2017/2018)
    (Vorlesung mit Übung, 2 SWS, Frank Wilhelm Heinemann et al., please contact Dr. Frank Heinmann (frank.heinemann@fau.de) latest till Friday in the first week of lectures!)
  • Modern X-ray structure determination of single crystals/Einführung i. d. Kristallstrukturbestimmung von Molekülverbindungen (SS 2018)
    (Vorlesung mit Übung, 2 SWS, Frank Wilhelm Heinemann et al., time and place by agreement; please contact Dr. Heinemann (frank.heinemann@fau.de) latest till Friday in the first week of lectures!)
• D. Advanced Organic Chemistry I (2L)
  • Advanced Organic Chemistry I - Synthesis and Catalysis/Fortgeschrittene Organische Chemie I - Synthese und Katalyse (WS 2017/2018)
    (Vorlesung, 2 SWS, Svetlana Tsogoeva et al., Fr, 10:15 - 11:45, C3 - Chemikum)
• E. Advanced Organic Chemistry II (2L)

  choice of 1 course from
  E1: Organocatalysis (2L)
  E2: Chemie der Naturstoffe (2L)
  E3: Radical Chemistry (2L)

  • Organocatalysis (SS 2018)
    (Vorlesung, 2 SWS, Svetlana Tsogoeva, Fr, 12:30 - 14:00, C3 - Chemikum)
  • Seminar: Chemie der Naturstoffe (SS 2018)
    (Hauptseminar, 2 SWS, Marcus Speck et al., Di, 10:00 - 12:00, 00.110)
  • Current issues in Organic Chemistry I/II (Advanced Organic Chemistry II) (SS 2018)
    (Seminar, 2 SWS, Andreas Hirsch et al., Di, 14:00 - 17:00, C3 - Chemikum; Attendance is compulsory in the first week of lectures!)

Inhalt:

A: Advanced chemical synthesis and molecular analysis

B: Inorganic and coordination chemistry principles; application of spectroscopic methods; advanced reaction mechanisms and experimental methods; important catalytic processes driven by metal complexes; design and synthesis of catalysts, physiologically active substances and new materials based on transition metals compounds

D: Modern synthetic methods in organic chemistry: pericyclic reactions, heterocycle syntheses, modern catalytic methodologies (metal-, organo- and biocatalysis), strategies in stereoselective synthesis

C1: Metal binding to proteins and DNA; functions of metal ions in enzymes; O₂transport, storage and activation; electron transfer in proteins; heme and non-heme iron containing oxygenases; zinc peptidases and proteases; superoxide dismutases; copper containing enzymes; biological function of nickel, molybdenum and tungsten; concepts and synthesis of model complexes; basics of Photosynthesis

C2: Platinum based anticancer drugs; Ruthenium and gold based metallotherapeutics; silapharmaca; Li therapeutics; boron neutron capture therapy; MnSOD; insulin mimetic vanadium containing compounds; magnetic resonance imaging (MRI); cobalamin; metal poisoning; Hg in the biosphere; metallotherapeutic arsenic compounds; technetium radiodiagnostics; antimony in medicine; bismuth based pharmaceuticals

C3: Synthesis of n-dimensional nano-materials. Systematic approaches towards nano-particles of defined size and structure are the basis to prepare materials with taylor-made electronic, optical or catalytic properties. The interplay between nano-particles, nano-rods, nano-wires, 2- and 3-dimentional materials are highlighted.

C4: Fundamentals of crystallization; polymorphism; structural description of crystals, crystal systems, unit cell, symmetry and symmetry elements, space groups; diffraction power of crystals, diffraction conditions, structure factor; generation of X-rays, single crystal diffractometers, data collection, data reduction; structure solution and refinement, problems and pitfalls, anomalous dispersion and absolute structure, interpretation of results, graphical representations, data bases.

E1: General concepts of organocatalysis. Enamine/iminiumion activation by Lewis basic amines. Noncovalent catalysis with ureas, thioureas and diols. Brønsted- and Lewis-acid catalysis. Phase-transfer catalysis. Bi- and multi-functional catalysts. Iminium/Enamine cascade catalysis. Organocatalytic domino reactions; natural product and chiral drug synthesis.

E2: Structure, isolation and structure elucidation of natural products; biosynthesis and degradation of carbon hydrates, lipids, peptides and terpenoids; biological and medicinal aspects of tetrapyrrols and alkaloids; technical synthesis of vitamins

E3: Radical reactivity; time scales and radical clock experiments; electrophilic and nucleophilic radicals; radical initiators; radical generation by oxidation or reduction; tin hydrides and modern replacements; atom and group transfer reactions; generation of various carbon-centered radicals; generation of oxygen- and nitrogencentered radicals.

Lernziele und Kompetenzen:

The students are able

• to understand and to explain the principles of advanced chemical synthesis routes and molecular analysis in organic and inorganic chemistry

• to understand the functionality of various molecular systems

• to participate in planning, developing and executing of experimental routes for the synthesis of more complex molecular systems

• to characterize molecular samples (natural compounds, e.g., peptides or vitamins, or metal-based drugs) using modern experimental methods and techniques

• to interpret and critically summarize experimental results in written form (lab report in paper-style format)

• to work in smaller research teams (team ability).

Organisatorisches:

Intended stage in the degree course: Mandatory elective module (Wahlpflichtmodul) or Elective module (Wahlmodul), semester 1-3
Frequency of offer: start of studies is available in summer and winter term
A: upon appointment with contact persons
B & D: winter term
E1/E2: summer term; E2 also winter term;
E3: winter term
C1/C2/C3: winter term

Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan:

1. Molecular Science (Master of Science)
   (Po-Vers. 2013 | NatFak | Molecular Science (Master of Science) | Wahlpflichtmodul Molecular Science)

Studien-/Prüfungsleistungen:

Molekülsynthesen - Molecular Synthesis (Prüfungsnummer: 30801)

(englischer Titel: Molecular Synthesis)

Prüfungsleistung, mündliche Prüfung, Dauer (in Minuten): 45, benotet

Anteil an der Berechnung der Modulnote: 100.0 %

weitere Erläuterungen:
Assessment and examinations: O45 (PL) + LAB (SL): Oral examination (45 min), 2 Examiners + Lab course protocol(s), ungraded

Calculation of the grade for the module: 100% from oral examination

Prüfungssprache: Englisch

Erstablegung: SS 2018, 1. Wdh.: WS 2018/2019

1. Prüfer:

Karsten Meyer