Schwerpunktfach Biomaterials and Bioprocessing (Bio focal)15.0 ECTS
(englische Bezeichnung: Focal subject Biomaterials and Bioprocessing)
(Prüfungsordnungsmodul: Schwerpunkt Biomaterials and Bioprocessing)

Lehrveranstaltungen:

• • Immobilisation of cells and characterisation of membranes (SS 2018)
    (Vorlesung, 2 SWS, Ruth Freitag, Block seminars will take place at Bayreuth University; dates will be organized by the MAP office)
  • Biomaterials for Tissue Engineering (SS 2018)
    (Vorlesung, 2 SWS, Aldo R. Boccaccini et al., Mo, 10:15 - 11:45, 3.71; ab 16.4.2018)
  • Biomimetic synthesis of materials (WS 2018/2019)
    (Vorlesung, 2 SWS, Stephan E. Wolf, Di, 14:15 - 15:45, 0.15)
  • Application of Cell Technology (WS 2018/2019)
    (Vorlesung, 2 SWS, Aldo R. Boccaccini et al., Di, 11:00 - 12:30, SemR-USS; ab 23.10.2018)
  • Polymerwerkstoffe in der Medizin (WS 2018/2019)
    (Vorlesung, 2 SWS, Joachim Kaschta, Mo, 10:15 - 11:45, 1.84; ab 22.10.2018)

Inhalt:

• Immobilisation system

• High density cell culture bioreactors

• Microcarriers - advantages and disadvantages

• Surface binding (adhesion)

• Matrix properties

• DLVO Theory

• Modified surfaces

• Flocculation and Coagulation

• Van der Waals Forces and electrostatic forces

• Principle of polymer flocculation

• Flocculation with yeast cells

• Flocculation breakage

• Floc strength

• Breakage models

• Antibody binding

• ELISA

• Tumor therapy

• Magnetic associated cell sorting (MACS)

• Entrapment methods

• Hollow fiber reactor

• Encapsulation

• Encapsulation technology

• Droplet formation

• Membrane characterization

• Categories of membranes for Life Science application

• Membrane materials

• Membrane based processes

• Applications in the biopharmaceutical industry and in medicine/medtech

Biomimetic Synthesis of Materials (Prof. Wolf):
The course "Biomimetic Materials and Processing" introduces the fundamental principles of design and processing which give rise to the key features exhibited by biological materials. Processes and concepts of growth, form, and development are discussed, with a special focus on evolutionary optimization strategies. Basic biochemical and microbiological aspects in respect to self-assembly, stimuli-response and adaptation of functional biomaterials are covered. Fundamental processes of biomineralization is discussed along with the key properties and functions which biominerals exhibit. The translation of these concepts to bio-inspired materials and processes for manufacturing biomimetic functional materials are presented along with the challenges and limits of such a biomimetic approach. The course is completed leading through smart materials and application prospects of biomimetic materials.

Application of cell technology (Dr. Detsch):
This course introduces the basics of biochemistry, cells and cell culture technique. Based on this knowledge, the students will learn how cells interact with biomaterials and how material parameters are influencing protein adsorption, cell adhesion, proliferation and differentiation. Also techniques to study these interactions are discussed in this course. With regards to biomedical engineering, characteristics of cell lines, primary and stem cells are further focal points. To understand the different approaches of tissue engineering, materials, growth factors and bioreactors will be discussed. Based on different hard and soft tissue examples, angiogenesis and tissue regeneration will be focused. Moreover, concepts of biofabrication will be introduced.

Lernziele und Kompetenzen:

Cells, Membranes and Tissue Engineering:
The students achieve extensive knowledge in the field of cell cultivation including cell immobilization, cell interaction and membrane interactions. Furthermore, the students analyze typical situations of application of membrane technology in the life sciences and to propose possible solutions based on understanding of both process and material aspects.

Biomimetic Materials:
The students

• elaborate differences between bionic and biomimetic sciences

• discuss the limits of biomimetic approaches

• identify and elaborate on the basic design principles in biological materials

• give an account on the structure, processing, and function of various classic examples of biological functional materials with a special regard to biological ceramic materials, i.e. biominerals

• adapt design concepts used in natural systems to synthesis for the development of new functional materials.

Application of Cell Technology:
The students have the knowledge of the application of cell tissue technologies for tissue engineering in medicine and biomedicine. The students can apply basic research methods e.g. application of cell based interdisciplinary research topics. As the students will discuss current research projects, students are able to interpret and evaluate in vitro data from several biomedical research studies.

Polymers in Medical Application:
The students understand which factors from the polymer structure (chemical as well as molecular), determine the use of certain polymers in a selected medical application. The students can apply their knowledge to choose a polymer for a given medical application. Additionally, ways of modifying polymers for certain applications are discussed (e.g. reinforcement, surface modification) together with its theoretical background. The students can analyse structure property relationships being relevant for medical applications of polymers.

Literatur:

• Immobilised cells and enzymes. J. Woodward. IRL Press Ltd. Oxford; ISBN 0-947946-21-7

• Membranes for Life Sciences Wiley-VCH (Ed. K.-V. Peinemann, S. Pereira-Nunes)
  

Biomimetic Materials:

• E Bäuerlein, Biomineralization, Wiley-VCH (2004)

• TX Fan, SK Chow, D Zhang, Biomorphic mineralization: From biology to materials, Progress in Materials Science 54 (2009) 542 - 659

• P Gomez-Romero, C Sanchez Functional Hybrid Materials, Wiley-VCH (2004)

Application of Cell Technology:

• Di Silvio (ed.): Cellular Response to Biomaterials; Cambridge u.a., 2009

• KC Dee, DA Puleo and R Bizios: Tissue-Biomaterial-Interaction; Wiley-Liss New Jersey, ISBN 0-471-25394-4

• B. D. Ratner et al. (eds.): Biomaterials Science, 2nd Ed., Elsevier, 2004.

Polymers in Medical Applications:

• Wintermantel E.; Ha, S.W.; Medizintechnik - Life Science Engineering, Springer, 5th. ed. 2009

• Mahapatro A. (ed.); Polymers for biomedical applications 2nd ed. Oxford, 2005

Weitere Informationen:

Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan:

1. Advanced Materials and Processes (Master of Science)
   (Po-Vers. 2017w | TechFak | Advanced Materials and Processes (Master of Science) | Schwerpunktfächer | Schwerpunkt Biomaterials and Bioprocessing)

Studien-/Prüfungsleistungen:

Biomaterials and Bioprocessing 1: Cells, Membranes and Tissue Engineering (Prüfungsnummer: 1806)

(englischer Titel: Biomaterials and Bioprocessing 1: Cells, Membranes and Tissue Engineering)

Prüfungsleistung, mündliche Prüfung, Dauer (in Minuten): 45, benotet, 7.5 ECTS

Anteil an der Berechnung der Modulnote: 50.0 %

Prüfungssprache: Englisch

Erstablegung: SS 2018, 1. Wdh.: WS 2018/2019

1. Prüfer:

Aldo R. Boccaccini

Biomaterials and Bioprocessing 2: Applied Biomaterials Synthesis and Cell-Materials Interactions (Prüfungsnummer: 1807)

(englischer Titel: Biomaterials and Bioprocessing 2: Applied Biomaterials Synthesis and Cell-Materials Interactions)

Prüfungsleistung, mündliche Prüfung, Dauer (in Minuten): 45, benotet, 7.5 ECTS

Anteil an der Berechnung der Modulnote: 50.0 %

Prüfungssprache: Englisch

Erstablegung: WS 2018/2019, 1. Wdh.: SS 2019

1. Prüfer:

Aldo R. Boccaccini,

2. Prüfer:

Joachim Kaschta

Termin: 22.03.2019