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Orientierungsmodul Structural Biology II: Structure and function relationships in biological macromolecules (OMA-StrBio2)7.5 ECTS (englische Bezeichnung: Orientierungsmodul Strukturbiologie II: Struktur-Funktionsbeziehungen in Biologischen Makromolekülen)
Modulverantwortliche/r: Yves Muller Lehrende:
Rainer Böckmann, Yves Muller, Benedikt Schmid
Studienfächer/Prüfungsordnungsmodule:
Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules (85216)
Startsemester: |
SS 2023 | Dauer: |
1 Semester | Turnus: |
jährlich (SS) |
Präsenzzeit: |
120 Std. | Eigenstudium: |
105 Std. | Sprache: |
Englisch |
Lehrveranstaltungen:
Empfohlene Voraussetzungen:
none
Inhalt:
Seminar talks cover theoretical and methodological approaches for the study of structure-function relationships in proteins with a focus on the structural determinants that are responsible for the regulation of protein function.
Laboratory course focuses on advanced methods to study structure-dynamics-function relationships in proteins. Both experimental (heterologous protein production in eukaryotic cells, X-ray analysis, mutation studies) as well as theoretical methods (atomistic and coarse-grained molecular dynamics simulations) will be addressed. Additionally, students are introduced to X-ray crystallography and investigating protein stability via CD spectroscopy in hands-on lab-training units.
The focus of the practical course will be the active participation in ongoing research projects in the participating labs.
Lernziele und Kompetenzen:
The students are
acquainted with novel insights, concepts, and methods in the study of protein-dynamics-function relationships
understand state-of-the-art methods in the analysis of protein structure, dynamics, function and their limitations
are able to independently develop working hypotheses, to independently design and conduct experiments
able to present and critically discuss current research articles / their results and defend their conclusions in proper context
Literatur:
introductory articles will be provided electronically
Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan: Das Modul ist im Kontext der folgenden Studienfächer/Vertiefungsrichtungen verwendbar:
- 643#65#H
(Po-Vers. 2012 | NatFak | Integrated Life Sciences: Biologie, Biomathematik, Biophysik (Master of Science) | Modulgruppen | MG1: Mathematische Modellierung und Systembiologie | Wahlpflichtmodule der Modulgruppe1 | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
- 643#65#H
(Po-Vers. 2012 | NatFak | Integrated Life Sciences: Biologie, Biomathematik, Biophysik (Master of Science) | Modulgruppen | MG2: Bioimaging und Biophysik | Wahlpflichtmodule der Modulgruppe2 | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
- 643#65#H
(Po-Vers. 2012 | NatFak | Integrated Life Sciences: Biologie, Biomathematik, Biophysik (Master of Science) | Modulgruppen | MG3: Biologische Strukturen und Prozesse | Wahlpflichtmodule der Modulgruppe3 | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
- Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science)
(Po-Vers. 2015w | NatFak | Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science) | Module Groups | MG3: Biological Structures and Processes | Mandatory Elective Modules Group 3 | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
- Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science)
(Po-Vers. 2019w | NatFak | Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science) | Module Groups | MG3: Biological Structures and Processes | Mandatory Elective Modules Group 3 | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
- Zell- und Molekularbiologie (Master of Science)
(Po-Vers. 2008 | NatFak | Zell- und Molekularbiologie (Master of Science) | alte Prüfungsordnungen | Mastermodule | Biologische Mastermodule | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
- Zell- und Molekularbiologie (Master of Science)
(Po-Vers. 2015w | NatFak | Zell- und Molekularbiologie (Master of Science) | Mastermodule | Biologische Mastermodule | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
- Zell- und Molekularbiologie (Master of Science)
(Po-Vers. 2019w | NatFak | Zell- und Molekularbiologie (Master of Science) | Orientierungsmodule | Biologische Orientierungsmodule | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
Studien-/Prüfungsleistungen:
Portfolio exam Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules (Prüfungsnummer: 22111)
zugeh. "mein campus"-Prüfung: | - 22111 Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules (Gewichtung: 100.0 %, Prüfung, Form: variabel, Zehntelnoten, Dauer: -, 7.5 ECTS, Prüfung).
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- Prüfungsleistung, mehrteilige Prüfung, benotet, 7.5 ECTS
- Anteil an der Berechnung der Modulnote: 100.0 %
- weitere Erläuterungen:
PL: written examination 90 min.
PL: protocol of 15-20 pages
PL: seminar talk 15 min.
- Erstablegung: SS 2023
1. Prüfer: | Böckmann/Muller (N40002) |
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