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ILS-MA-B14: Molecular dynamics simulation of biological membranes (MG1_Simulation)7.5 ECTS (englische Bezeichnung: Simulation biologischer Membranen)
(Prüfungsordnungsmodul: Molecular dynamics simulation of biological membranes)
Modulverantwortliche/r: Rainer Böckmann Lehrende:
Rainer Böckmann
Startsemester: |
SS 2021 | Dauer: |
1 Semester | Turnus: |
jährlich (SS) |
Präsenzzeit: |
90 Std. | Eigenstudium: |
135 Std. | Sprache: |
Englisch |
Lehrveranstaltungen:
Inhalt:
Theory and Practice of Molecular Dynamics Simulations
Membranes:
Composition of biological membranes, structure, dynamics, asymmetry, spontaneous association of lipids to membranes, role of cholesterol, domain formation in membranes (‘lipid rafts’), protein-lipid interaction, receptor clustering
Theory:
physical interactions in MD simulations, Newton’s equations of motion, integration of equations of motion, temperature control in simulations, boundary conditions, static and dynamic properties in biomolecular systems
Practice (Computer Lab):
Introduction to Python, implementation of MD simulation in Python, programming of simple analysis tools, introduction into simulation of membrane systems (Gromacs package)
Lernziele und Kompetenzen:
The students are able to
describe and explain standard methodologies in MD simulations
possess profound knowledge in theory of biomolecular interactions
learn the programming language Python
acquire problem-oriented programming strategies using Python
understand and explain molecular driving forces in domain formation of biomembranes
Literatur:
Daan Frenkel, Berend Smit: „Understanding Molecular Simulation“
Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan:
- Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science)
(Po-Vers. 2019w | NatFak | Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science) | Module Groups | MG3: Biological Structures and Processes | Molecular dynamics simulation of biological membranes)
Studien-/Prüfungsleistungen:
Molecular dynamics simulation of biological membranes (Prüfungsnummer: 22941)
- Prüfungsleistung, mehrteilige Prüfung, benotet, 7.5 ECTS
- Anteil an der Berechnung der Modulnote: 100.0 %
- weitere Erläuterungen:
PL: oral examination (30 min.)
PL: project work & protocol (approx. 10 pages)
- Erstablegung: SS 2021, 1. Wdh.: WS 2021/2022
1. Prüfer: | Rainer Böckmann |
- Termin: 19.07.2021, 10:00 Uhr, Ort: CIP Biologie (U1.131, Staudtstr.5, 91058 Erlangen)
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