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Drug discovery (MSM-life)30 ECTS (englische Bezeichnung: Drug discovery)
Modulverantwortliche/r: Peter Gmeiner Lehrende:
Peter Gmeiner, Andreas Burkovski, Jürgen Schatz, Jutta Eichler, Markus Heinrich, u.a.
Studienfächer/Prüfungsordnungsmodule:
Pflichtmodul Molecular Science (20195)
Startsemester: |
WS 2017/2018 | Dauer: |
2 Semester | Turnus: |
jährlich (WS) |
Präsenzzeit: |
450 Std. | Eigenstudium: |
450 Std. | Sprache: |
Englisch |
Lehrveranstaltungen:
Mandatory courses:
Seminars:
Drug Discovery-SEMINAR (7SEM)
Drug Discovery-Laboratory course (23LAB): 10 week block lab project in one of the participating research groups (Profs. Burkovski, Burzlaff, Eichler, Gmeiner, Heinrich, Ivanovic-Burmazovic, Koch, Lanig, Muller, Nitschke, Schatz, Stadler, Winkler, Zahn)
with
Seminar Research projects (1S): oral presentation (20
min, plus discussion)
Seminar Journal club (group seminar in one of the research groups)(2S)
Please note: attendance in lab course is compulsory!
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Drug Discovery Praktikum (WS 2017/2018)
(Praktikum, 23 SWS, Peter Gmeiner et al., Zeit und Raum n.V.)
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Drug Discovery Seminar (WS 2017/2018)
(Seminar, 7 SWS, Andreas Burkovski et al., Mo, 14:15 - 16:00, C4 - Chemikum; Di, 14:15 - 17:00, C4 - Chemikum; Mi, 17:00 - 19:00, C4 - Chemikum; Start/Beginn (Introduction/Einführungsveranstaltung): Monday, 16th october 2017, 14:30 , C4, Please join on StudOn: Drug Discovery (MSM-Life))
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Drug Discovery Praktikum (SS 2018)
(Praktikum, 23 SWS, Peter Gmeiner et al., Zeit und Raum n.V.)
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Drug Discovery Seminar (SS 2018)
(Seminar, 7 SWS, Andreas Burkovski et al., Mo, 14:00 - 16:00, C4 - Chemikum; Di, 14:30 - 17:00, C4 - Chemikum; Mi, 17:00 - 19:00, C4 - Chemikum; Einzeltermine am 16.7.2018, 17.7.2018, 8:00 - 18:00, C4 - Chemikum; ab 10.4.2018; ; Presentation of Projects: Monday, 16. July 2018 and Tuesday, 17. July 2018; Seminar start in summerterm 2018: Tuesday, 10.4.2018)
Inhalt:
Drug Discovery-SEMINAR
Genomics, transcriptomics, proteomics; in-vitro assay systems, assay technology; target screening and drug production in plants, drug screening and production in yeast; experimental structural biology; chemoinformatics; molecular modeling: molecular dynamics simulation, force-fields, modeling of proteins, proteinligand docking; drug synthesis and combinatorial chemistry; redox-active metal complexes,
metalloenzyme inhibitors; stereochemistry in drug design; organic reactions in medicinal chemistry; drug metabolism; peptidomimetics;
LAB Course
Project course: Lab projects focusing on the modern research issues in one of the participating research groups.
Seminar research projects:
students reports on lab projects.
Discussions on recent publications in the field of drug discovery (within the respective research units).
Lernziele und Kompetenzen:
The students are able
to understand the basic and advanced principles of medicinal chemical, molecular biological and computer
chemistry based applications in the field of modern drug design research
to utilize modern experimental techniques to prepare and characterize various samples with in the lab project
to apply modern simulation techniques for the modeling of proteins
to interpret and to critically summarize experimental results in written form (lab report), and to present and discuss these results within the research group or in front of a student audience
to participate in planning, developing and executing of experimental routes for the synthesis of drugs
to judge and to discuss in oral form their research results in the field of drug discovery in comparison to recent publications.
Literatur:
Manuscripts are available on StudON,
additional reading, e.g. G. Klebe, Drug Design: Methodology, Concepts, and Mode-of-Action, Springer 2013
Bemerkung:
Courses of study for which the module is acceptable:
M.Sc. Molecular Lifescience
Organisatorisches:
Frequency of offer: Annually / start of studies is strongly recommended in winter term
Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan: Das Modul ist im Kontext der folgenden Studienfächer/Vertiefungsrichtungen verwendbar:
- Molecular Science (Master of Science)
(Po-Vers. 2013 | NatFak | Molecular Science (Master of Science) | Pflichtmodul Molecular Science)
Studien-/Prüfungsleistungen:
Drug Discovery (Prüfungsnummer: 30702)
(englischer Titel: Drug Discovery)
zugeh. "mein campus"-Prüfung: | - 30702 Drug Discovery (Prüfung, Form: mündliche Prüfung, Zehntelnoten, Dauer: -, 30 ECTS, Prüfung).
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- Prüfungsleistung, mündliche Prüfung, Dauer (in Minuten): 45, benotet
- Anteil an der Berechnung der Modulnote: 100.0 %
- weitere Erläuterungen:
Assessment and examinations:
PL Oral examination (O 45min, 3 examiners), LEC (PL), LAB (PL)*
*Lab course protocol (without explicit mark) + oral presentation of research project (20 min + discussion);
Calculation of the grade for the module:
PL: O45 (66 %), LEC (PL) (17 %), LAB (PL) (17 %)
- Prüfungssprache: Englisch
- Erstablegung: SS 2018, 1. Wdh.: WS 2018/2019
1. Prüfer: | Peter Gmeiner (070604) |
1. Prüfer: | Jürgen Schatz (070406) |
1. Prüfer: | Jutta Eichler (070607) |
1. Prüfer: | Markus Heinrich (070608) |
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