Orientierungsmodul Structural Biology II: Structure and function relationships in biological macromolecules (OMA-StrBio2)7.5 ECTS
(englische Bezeichnung: Orientierungsmodul Strukturbiologie II: Struktur-Funktionsbeziehungen in Biologischen Makromolekülen)

Lehrveranstaltungen:

• • Orientierungsmodul Strukturbiologie II: Structure und function relationships in biotechnologically relevant macromolecules
    (Übung, 8 SWS, Yves Muller et al., 8:00 - 18:00, Kursraum N-I, Kursraum N-II; For more informations please visit Studon: https://www.studon.fau.de/crs2861283.html)

Empfohlene Voraussetzungen:

none

Inhalt:

Seminar talks cover theoretical and methodological approaches for the study of structure-function relationships in proteins with a focus on the structural determinants that are responsible for the regulation of protein function.
Laboratory course focuses on advanced methods to study structure-dynamics-function relationships in proteins. Both experimental (heterologous protein production in eukaryotic cells, X-ray analysis, mutation studies) as well as theoretical methods (atomistic and coarse-grained molecular dynamics simulations) will be addressed. Additionally, students are introduced to X-ray crystallography and investigating protein stability via CD spectroscopy in hands-on lab-training units. The focus of the practical course will be the active participation in ongoing research projects in the participating labs.

Lernziele und Kompetenzen:

The students are

• acquainted with novel insights, concepts, and methods in the study of protein-dynamics-function relationships

• understand state-of-the-art methods in the analysis of protein structure, dynamics, function and their limitations

• are able to independently develop working hypotheses, to independently design and conduct experiments

• able to present and critically discuss current research articles / their results and defend their conclusions in proper context
  

Literatur:

introductory articles will be provided electronically

Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan:
Das Modul ist im Kontext der folgenden Studienfächer/Vertiefungsrichtungen verwendbar:

1. 643#65#H
   (Po-Vers. 2012 | NatFak | Integrated Life Sciences: Biologie, Biomathematik, Biophysik (Master of Science) | Modulgruppen | MG1: Mathematische Modellierung und Systembiologie | Wahlpflichtmodule der Modulgruppe1 | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
2. 643#65#H
   (Po-Vers. 2012 | NatFak | Integrated Life Sciences: Biologie, Biomathematik, Biophysik (Master of Science) | Modulgruppen | MG2: Bioimaging und Biophysik | Wahlpflichtmodule der Modulgruppe2 | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
3. 643#65#H
   (Po-Vers. 2012 | NatFak | Integrated Life Sciences: Biologie, Biomathematik, Biophysik (Master of Science) | Modulgruppen | MG3: Biologische Strukturen und Prozesse | Wahlpflichtmodule der Modulgruppe3 | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
4. Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science)
   (Po-Vers. 2015w | NatFak | Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science) | Module Groups | MG3: Biological Structures and Processes | Mandatory Elective Modules Group 3 | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
5. Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science)
   (Po-Vers. 2019w | NatFak | Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science) | Module Groups | MG3: Biological Structures and Processes | Mandatory Elective Modules Group 3 | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
6. Zell- und Molekularbiologie (Master of Science)
   (Po-Vers. 2008 | NatFak | Zell- und Molekularbiologie (Master of Science) | alte Prüfungsordnungen | Mastermodule | Biologische Mastermodule | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
7. Zell- und Molekularbiologie (Master of Science)
   (Po-Vers. 2015w | NatFak | Zell- und Molekularbiologie (Master of Science) | Mastermodule | Biologische Mastermodule | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)
8. Zell- und Molekularbiologie (Master of Science)
   (Po-Vers. 2019w | NatFak | Zell- und Molekularbiologie (Master of Science) | Orientierungsmodule | Biologische Orientierungsmodule | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)

Studien-/Prüfungsleistungen:

Portfolio exam Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules (Prüfungsnummer: 22111)

Prüfungsleistung, mehrteilige Prüfung, benotet, 7.5 ECTS

Anteil an der Berechnung der Modulnote: 100.0 %

weitere Erläuterungen:
PL: written examination 90 min. PL: protocol of 15-20 pages PL: seminar talk 15 min.

Erstablegung: SS 2023

1. Prüfer:

Böckmann/Muller