Immun-Biotechnologie (ImmuTec)5 ECTS
(englische Bezeichnung: Immune-Biotechnology)
(Prüfungsordnungsmodul: Immun-Biotechnologie)

Lehrveranstaltungen:

• • Immun-Biotechnologie
    (Vorlesung, 2 SWS, Michael Haug et al., Di, 14:15 - 15:45, SR 00.030)
  • Übung zu Immun-Biotechnologie
    (Übung, 1 SWS, Michael Haug et al., Mo, 10:15 - 11:45, SR 00.030)

Empfohlene Voraussetzungen:

• Basic knowledge in immunology (e.g. through Bachelor course MBT of LSE)

• Previous courses on bioprocess engineering and genetic engineering
  

Inhalt:

Lecture:

• Immune system revision: immune reaction, cellular and humoral adaptive and innate immune defence system

• Process pipelines for antibody (AB) production: polyclonal, monoclonal, recombinant Abs, biosystems and bioreactor

• Downstream processing of Abs

• Diagnostic and therapeutic AB formulations

• Vaccine Technologies

• Genetic immune modulation technologies Crspr/Cas9

• Manipulation of immune cells and host immune mediators for targeted therapies in Personalized Medicine, e.g. in cancer, HIV, auto-immune disease, malaria, leukaemia

• Organ transplantation: organ rejection through immune incompatibilities, immune-suppression, biotechnology strategies

• Recombinant production of immune-modulatory signaling molecules

• New trends in diagnostic immune-technologies (e.g. label-free point-of-care systems, blood analyser, etc.)

• Nano-immuno-technology
  

Seminar (exercise course):

• The seminar will be designed in a scenario-group approach where students shall analyse a scenario, define the problem, research for respective solutions, evaluate and reflect on them and present to the class
  

Lernziele und Kompetenzen:

Students shall

• learn and understand the concepts of innate versus adaptive immune reaction

• comprehend ways to manipulate immune system reaction through humoral and cellular means

• embrace the relationship between genetic diversity and immunologi-cal compatibility and be able to depict strategies for genetic manipula-tion to enforce such compatibility

• be able to understand the concept of Personalized Medicine in de-signing tailored immune-strategies for selected diseases and name strategies to target immune cells, cancer cells and pathogens

• be able to critically evaluate the technological advances over the indi-vidual benefits and risks associated with immune biotechnology approaches
  

Literatur:

• Literature recommendations will be available through the lecture slide references

• Since the field is a young an actively developing field, there are not many text-books available!

• Anadurai D (2010) A textbook of Immunology & Immunotechnology. S Chand & Co Ltd. ISBN-13: 978-8121928076
  

Weitere Informationen:

Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan:

1. Life Science Engineering (Master of Science)
   (Po-Vers. 2019w | TechFak | Life Science Engineering (Master of Science) | Gesamtkonto | Wahlpflichtmodule | Immun-Biotechnologie)

Studien-/Prüfungsleistungen:

Immun-Biotechnologie (Prüfungsnummer: 51611)

(englischer Titel: Immune-Biotechnology)

Prüfungsleistung, Klausur, Dauer (in Minuten): 90, benotet

Anteil an der Berechnung der Modulnote: 100.0 %

Prüfungssprache: Deutsch oder Englisch

Erstablegung: WS 2022/2023, 1. Wdh.: SS 2023

1. Prüfer:

Oliver Friedrich