Drug discovery (MSM-life)30 ECTS
(englische Bezeichnung: Drug discovery)
(Prüfungsordnungsmodul: Pflichtmodul Molecular Science)

Lectures:

• Mandatory courses:
  Seminars:
  Drug Discovery-SEMINAR (7SEM)
  Drug Discovery-Laboratory course (23LAB): 10 week block lab project in one of the participating research groups (Profs. Burkovski, Burzlaff, Eichler, Gmeiner, Heinrich, Ivanovic-Burmazovic, Koch, Lanig, Muller, Nitschke, Schatz, Stadler, Winkler, Zahn)
  with
  Seminar Research projects (1S): oral presentation (20 min, plus discussion)
  Seminar Journal club (group seminar in one of the research groups)(2S)
  Please note: attendance in lab course is compulsory!

  • Drug Discovery Praktikum (WS 2018/2019)
    (Praktikum, 23 SWS, Peter Gmeiner et al., Zeit und Raum n.V.)
  • Drug Discovery Seminar (WS 2018/2019)
    (Seminar, 7 SWS, Andreas Burkovski et al., Mon, 14:15 - 16:00, C4 - Chemikum; Tue, 14:15 - 17:00, C4 - Chemikum; Wed, 17:00 - 19:00, C4 - Chemikum; Start/Beginn (Introduction/Einführungsveranstaltung): Tuesday, 16th october 2018, 14:15 , C4, Please join on StudOn: Drug Discovery (MSM-life) WS 2018/19 and SS 2019, Lecture on wednesdays only after special announcement)
  • Drug Discovery Praktikum (SS 2019)
    (Praktikum, 23 SWS, Peter Gmeiner et al., Zeit und Raum n.V.)
  • Drug Discovery Seminar (SS 2019)
    (Seminar, 7 SWS, Andreas Burkovski et al., Mon, 14:00 - 16:00, C4 - Chemikum; Tue, 14:30 - 17:00, C4 - Chemikum; Wed, 17:00 - 19:00, C4 - Chemikum; single appointment on 29.7.2019, single appointment on 30.7.2019, 8:00 - 18:00, C4 - Chemikum; Start: Tuesday, 23rd april 2019; Wednesdays after special announcement; Presentation of Projects: Monday, 29. July 2019 and Tuesday, 30. July 2019;)

Inhalt:

Drug Discovery-SEMINAR
Genomics, transcriptomics, proteomics; in-vitro assay systems, assay technology; target screening and drug production in plants, drug screening and production in yeast; experimental structural biology; chemoinformatics; molecular modeling: molecular dynamics simulation, force-fields, modeling of proteins, proteinligand docking; drug synthesis and combinatorial chemistry; redox-active metal complexes, metalloenzyme inhibitors; stereochemistry in drug design; organic reactions in medicinal chemistry; drug metabolism; peptidomimetics;
LAB Course
Project course: Lab projects focusing on the modern research issues in one of the participating research groups. Seminar research projects: students reports on lab projects. Discussions on recent publications in the field of drug discovery (within the respective research units).

Lernziele und Kompetenzen:

The students are able

• to understand the basic and advanced principles of medicinal chemical, molecular biological and computer

• chemistry based applications in the field of modern drug design research

• to utilize modern experimental techniques to prepare and characterize various samples with in the lab project

• to apply modern simulation techniques for the modeling of proteins

• to interpret and to critically summarize experimental results in written form (lab report), and to present and discuss these results within the research group or in front of a student audience

• to participate in planning, developing and executing of experimental routes for the synthesis of drugs

• to judge and to discuss in oral form their research results in the field of drug discovery in comparison to recent publications.

Literatur:

Manuscripts are available on StudON,
additional reading, e.g. G. Klebe, Drug Design: Methodology, Concepts, and Mode-of-Action, Springer 2013

Bemerkung:

Courses of study for which the module is acceptable: M.Sc. Molecular Lifescience

Organisatorisches:

Frequency of offer: Annually / start of studies is strongly recommended in winter term

Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan:

1. Molecular Science (Master of Science)
   (Po-Vers. 2013 | NatFak | Molecular Science (Master of Science) | Pflichtmodul Molecular Science)

Studien-/Prüfungsleistungen:

Drug Discovery (Prüfungsnummer: 30702)

(englischer Titel: Drug Discovery)

Prüfungsleistung, mündliche Prüfung, Dauer (in Minuten): 45, benotet

Anteil an der Berechnung der Modulnote: 100.0 %

weitere Erläuterungen:
Assessment and examinations: PL Oral examination (O 45min, 3 examiners), LEC (PL), LAB (PL)*
*Lab course protocol (without explicit mark) + oral presentation of research project (20 min + discussion);
Calculation of the grade for the module: PL: O45 (66 %), LEC (PL) (17 %), LAB (PL) (17 %)

Prüfungssprache: Englisch

Erstablegung: SS 2019, 1. Wdh.: WS 2019/2020

1. Prüfer:

Peter Gmeiner

1. Prüfer:

Jürgen Schatz

1. Prüfer:

Jutta Eichler

1. Prüfer:

Markus Heinrich