Biomaterials and Bioprocessing 2 (PF MAP-S-BMP 3)7.5 ECTS
(englische Bezeichnung: Biomaterials and Bioprocessing 2)
(Prüfungsordnungsmodul: Schwerpunktfach Biomaterials and Bioprocessing 2)

Lehrveranstaltungen:

• • Biomimetic synthesis of materials
    (Vorlesung, 2 SWS, Stephan E. Wolf, Di, 8:15 - 9:45, 0.15)
  • Application of Cell Technology
    (Vorlesung, 2 SWS, Aldo R. Boccaccini et al., Mi, 08:15 - 09:45, 0.154-115)
  • Polymerwerkstoffe in der Medizin
    (Vorlesung, 2 SWS, Joachim Kaschta, Di, 10:15 - 11:45, 0.68)

Inhalt:

Application of cell technology:

• basics of cell-biomaterial interactions

• protein-, cell-, blood-surface interactions

• inflammation and wound healing

• bioactivity and surface bioreactivity

• biocompatibility - basics of cell cultures and stem cells

• Case studies: tissue engineering - hard tissue

• Case studies: tissue engineering - soft tissue
  

Biomimetic Synthesis of Materials: The course "Biomimetic Materials and Processing" introduces to the principles of growth, form and evolutionary optimisation strategies. Basic biochemical and microbiological in respect to self-assembly, stimuli-response and adaptation are covered. The key properties and functions biominerals are discussed. The fundamental biomineralisation processes are introduced Bio-inspired concepts and processes for manufacturing biomimetic, inorganic functional materials are presented. The course is completed leading through smart materials and application prospects of biomimetic materials.

• INTRODUCTION

  • Nature and Technology, Bionic Science, Biomimetic Science
    

• FUNDAMENTAL ASPECTS OF BIOLOGICAL MATERIALS

  • Evolution, Biological Materials, Biological versus Engineering Materials
    

• BASICS IN BIOCHEMISTRY

  • The chemical bond, Biopolymers and Lipids, Cell Biology
    

• BIOMINERALISATION AND BIOMINERALS

  • Crystallisation, Types Biomineralisation and Biominerals
    

• BIOINSPIRED STRATEGIES FOR INORGANIC MATERIALS PROCESSING

  • Principles, Powders, 1D Templates: fibers, 2D Structure & surface mineralization, 3D Assemblies & cellular composites, Biotemplating & genetic engineering
    

• POTENTIAL APPLICATIONS

  • Life Sciences: Biomedical Materials, - Engineering: Biomimetic Materials, Energy and Environmental Materials
    

Polymers in Medical Application:

• overview on polymers in medical applications

• polymers and polymer composites in bone replacement and artificial joints

• resorbable polymers in implants – biodegradability of polymers

• polymers in drug delivery systems

• polymers for medical applications with blood contact (artificial blood vessels, artificial heart valves, artificial hearts,) – thrombogenicity of polymer surfaces.

• sterilization of polymers

• antimicrobial polymers

• polymers for catheters

• polymer and polymer composites for dental applications

• scaffolds from polymers for tissue engineering

• polymers for sinews and ligament replacement

  • polymers in ophtamology

Lernziele und Kompetenzen:

Application of Cell Technology: The lecture enables the students the knowledge of the application of cell techniques for tissue engineering in regenerative medicine
Biomimetic Materials: The lecture enables the students …

• to elaborate differences between bionic and biomimetic sciences

• identify the basic principles of biological materials and their assembly in biological processes, esp. biominerals and biomineralisation
  

• to transfer fundamental knowledge on cells and the biopolymers involved in biomineral formation for materials synthesis

• how to generate a new class of materials using biological principles

Polymers in Medical Application: The lecture enables the students to understand which factors from the polymer structure (chemical as well as molecular) determine the use of certain polymers in a selected medical application. The student will learn how to choose a polymer for a given medical application. Additionally, ways of modifying polymers for certain applications are discussed (e.g. reinforcement, surface modification) together with its theoretical background. The student gets insight into structure-property relationships being relevant for medical applications of polymers.

Literatur:

Application of Cell Technology: -- Di Silvio (ed.): Cellular Response to Biomaterials; Cambridge u.a., 2009

• KC Dee, DA Puleo and R Bizios: Tissue-Biomaterial-Interaction; Wiley-Liss New Jersey, ISBN 0-471-25394-4

• B. D. Ratner et al. (eds.): Biomaterials Science, 2nd Ed., Elsevier, 2004.
  

Biomimetic Materials:

• E Bäuerlein, Biomineralization, Wiley-VCH (2004)

• TX Fan, SK Chow, D Zhang, Biomorphic mineralization: From biology to materials, Progress in Materials Science 54 (2009) 542–659

• P Gomez-Romero, C Sanchez Functional Hybrid Materials, Wiley-VCH (2004)
  

Polymers in Medical Applications:

• Wintermantel E.; Ha, S.W.; Medizintechnik – Life Science Engineering, Springer, 5th. ed. 2009

• Mahapatro A. (ed.); Polymers for biomedical applications 2nd ed. Oxford, 2005 ....

Bemerkung:

Beginn ab KW 43

Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan:

1. Advanced Materials and Processes (Master of Science with Honours)
   (Po-Vers. 2014w | TechFak | Advanced Materials and Processes (Master of Science with Honours) | Masterprüfung | Schwerpunktfächer | Schwerpunktfach Biomaterials and Bioprocessing 2)

Studien-/Prüfungsleistungen:

Biomimetic Materials and Processes (Prüfungsnummer: 1921)

(englischer Titel: Biomimetic Materials and Processes)

Untertitel: Biomimetic synthesis of materials

(englischer Untertitel: Biomimetic synthesis of materials)

Prüfungsleistung, mündliche Prüfung, Dauer (in Minuten): 10, benotet

Anteil an der Berechnung der Modulnote: 0.0 %

Prüfungssprache: Englisch

Erstablegung: WS 2016/2017, 1. Wdh.: SS 2017

1. Prüfer:

Stephan E. Wolf

Application of Cell Technology (Prüfungsnummer: 1922)

(englischer Titel: Application of Cell Technology)

Untertitel: Application of Cell Technology

Prüfungsleistung, mündliche Prüfung, Dauer (in Minuten): 10, benotet

Anteil an der Berechnung der Modulnote: 0.0 %

Prüfungssprache: Englisch

Erstablegung: WS 2016/2017, 1. Wdh.: SS 2017

1. Prüfer:

Aldo R. Boccaccini

Polymerwerkstoffe in der Medizin (Prüfungsnummer: 1923)

(englischer Titel: Polymeric Materials in Medicine)

Prüfungsleistung, mündliche Prüfung, Dauer (in Minuten): 10, benotet

Anteil an der Berechnung der Modulnote: 0.0 %

Prüfungssprache: Englisch

Erstablegung: WS 2016/2017, 1. Wdh.: SS 2017

1. Prüfer:

Joachim Kaschta

Termin: 22.02.2018, 09:00 Uhr, Ort: 1.68