Orientierungsmodul Structural Biology II: Structure and function relationships in biological macromolecules (OMA-StrBio2)7.5 ECTS
(englische Bezeichnung: Orientierungsmodul Strukturbiologie II: Struktur-Funktionsbeziehungen in Biologischen Makromolekülen)
(Prüfungsordnungsmodul: Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)

Lehrveranstaltungen:

• • Orientierungsmodul Strukturbiologie II: Structure und function relationships in biotechnologically relevant macromolecules
    (Übung, 8 SWS, Yves Muller et al., 8:00 - 18:00, Kursraum N-I, Kursraum N-II; Einzeltermine am 19.4.2022, 20.4.2022, 21.4.2022, 9:15 - 10:45, Hörsaal ZMPT; 22.4.2022, 10:15 - 11:45, Seminarraum ZMPT; 25.4.2022, 9:15 - 10:45, Hörsaal ZMPT; 26.4.2022, 27.4.2022, 9:15 - 10:45, CIP Biologie; 2.5.2022, 5.5.2022, 9:15 - 10:00, Seminarraum ZMPT; 10.5.2022, 9:15 - 12:00, SR Biologie; 13.5.2022, 11:15 - 12:45, Seminarraum ZMPT; 29.7.2022, 9:15 - 18:00, Seminarraum ZMPT; For more informations please visit Studon: https://www.studon.fau.de/crs2861283.html)

Empfohlene Voraussetzungen:

none

Inhalt:

Seminar talks cover theoretical and methodological approaches for the study of structure-function relationships in proteins with a focus on the structural determinants that are responsible for the regulation of protein function.
Laboratory course focuses on advanced methods to study structure-dynamics-function relationships in proteins. Both experimental (heterologous protein production in eukaryotic cells, X-ray analysis, mutation studies) as well as theoretical methods (atomistic and coarse-grained molecular dynamics simulations) will be addressed. Additionally, students are introduced to X-ray crystallography and investigating protein stability via CD spectroscopy in hands-on lab-training units. The focus of the practical course will be the active participation in ongoing research projects in the participating labs.

Lernziele und Kompetenzen:

The students are

• acquainted with novel insights, concepts, and methods in the study of protein-dynamics-function relationships

• understand state-of-the-art methods in the analysis of protein structure, dynamics, function and their limitations

• are able to independently develop working hypotheses, to independently design and conduct experiments

• able to present and critically discuss current research articles / their results and defend their conclusions in proper context
  

Literatur:

introductory articles will be provided electronically

Verwendbarkeit des Moduls / Einpassung in den Musterstudienplan:

1. Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science)
   (Po-Vers. 2019w | NatFak | Integrated Life Sciences: Biology, Biomathematics, Biophysics (Master of Science) | Module Groups | MG3: Biological Structures and Processes | Mandatory Elective Modules Group 3 | Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules)

Studien-/Prüfungsleistungen:

Portfolio exam Structural Biology II: Structure and Function Relationships in Biotechnologically Relevant Macromolecules (Prüfungsnummer: 22111)

Prüfungsleistung, mehrteilige Prüfung, benotet, 7.5 ECTS

Anteil an der Berechnung der Modulnote: 100.0 %

weitere Erläuterungen:
PL: written examination 90 min. PL: protocol of 15-20 pages PL: seminar talk 15 min.

Erstablegung: SS 2022

1. Prüfer:

Böckmann/Muller