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Einrichtungen >> Medizinische Fakultät (Med) >> Institut für Biochemie >>

Lehrstuhl für Biochemie und Pathobiochemie (Prof. Dr. Wegner)

	2018 Analysis of the human SOX10 mutation Q377X in mice and its implications for genotype-phenotype correlation in SOX10-related human disease. In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy Injury-activated glial cells promote wound healing of the adult skin in mice. Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning. Oncogenic insult to the brain: Sox proteins rise to the occasion. Sox8 and Sox10 jointly maintain myelin gene expression in oligodendrocytes. Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT).
	2017 Ablation of protein kinase CK2? in skeletal muscle fibers interferes with their oxidative capacity BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation. MicroRNAs promote skeletal muscle differentiation of mesodermal iPSC-derived progenitors Myelin Regulatory Factor 1 Drives Remyelination in Multiple Sclerosis. Novel mutation in CNTNAP1 results in congenital hypomyelinating neuropathy. Reduced muscle strength in ether lipid-deficient mice is accompanied by altered development and function of the neuromuscular junction SoxE factors: Transcriptional regulators of neural differentiation and nervous system development. Sp2 is the only glutamine-rich Specificity protein with minor impact on development and differentiation in myelinating glia. Transcription factor Sox10 regulates oligodendroglial Sox9 levels via microRNAs.
	2016 α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy. Functional characterization of DNA methylation in the oligodendrocyte lineage. LAP proteins are localized at the post-synaptic membrane of neuromuscular junctions and appear to modulate synaptic morphology and transmission Neuromuscular endplate pathology in recessive desminopathies Schwann cells and their transcriptional network: Evolution of key regulators of peripheral myelination. SomethiNG 2 talk about-Transcriptional regulation in embryonic and adult oligodendrocyte precursors. Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes. Substantial DNA Methylation Differences between Two Major Neuronal Subtypes in Human Brain. The dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in myelinating oligodendrocytes. The impact of autophagy on peripheral synapses in health and disease Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain. Wnt/?-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and tead1, active in IIa/IIx muscle fibers Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair.
	2015 Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma. Brg1-dependent chromatin remodelling is not essentially required during oligodendroglial differentiation. Copy Number Variation of Two Separate Regulatory Regions Upstream of SOX9 Cause Isolated 46,XY or 46,XX Disorder of Sex Development. Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice. Elevated in vivo levels of a single transcription factor directly convert satellite glia into oligodendrocyte-like cells. From CNS stem cells to neurons and glia: Sox for everyone. Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination. Neural stem/progenitor cell properties of glial cells in the adult mouse auditory nerve. Orchestration of Neuronal Differentiation and Progenitor Pool Expansion in the Developing Cortex by SoxC Genes Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3?, and Dok-7 proteins and phosphorylates the latter two Radial glia phagocytose axonal debris from degenerating over-extending axons in the developing olfactory bulb. Sox5 controls dorsal progenitor and interneuron specification in the spinal cord. Transcription factors Sox10 and Sox2 functionally interact with positive transcription elongation factor b in Schwann cells.
	2014 α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy. Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types. Dysfunction of spatacsin leads to axonal pathology in SPG11-linked hereditary spastic paraplegia Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS. Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells. Lambert-Eaton myasthenic syndrome - Diagnosis, pathogenesis and therapy Mutual Antagonism Between Sox10 and NFIA Regulates Diversification of Glial Lineages and Glioma Sub-Types. Sox2: A multitasking networker. Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes. Targeted deletion of Sox10 by Wnt1-cre defects: neuronal migration and projection in the mouse inner ear.
	2013 A dual role for SOX10 in the maintenance of the postnatal melanocyte lineage and the differentiation of melanocyte stem cell progenitors. Expression of Sox4 and Sox11 is regulated by multiple mechanisms during retinal development. Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells. Mighty bugs: leprosy bacteria turn schwann cells into stem cells. MYRF is a Membrane-Associated Transcription Factor that Autoproteolytically Cleaves to Directly Activate Myelin Genes. Neural Crest Origin of Retinal and Choroidal Pericytes. Olfactory ensheathing glia are required for embryonic olfactory axon targeting and the migration of gonadotropin-releasing hormone neurons. Sox appeal – Sox10 attracts epigenetic and transcriptional regulators in myelinating glia. Sox10 cooperates with the Mediator subunit 12 during terminal differentiation of myelinating glia. The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells. The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes.
	2012 Chromatin remodelling factor Brg1 is required for Schwann cell differentiation and myelination. Desert Hedgehog links transcription factor Sox10 to perineurial development. Establishment of myelinating Schwann cells and barrier integrity between central and peripheral nervous systems depend on Sox10. Nuclear factor erythroid-derived 2 (Nfe2) regulates junD DNA-binding activity via acetylation: A novel mechanism regulating trophoblast differentiation Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation. Sox10 promotes the formation and maintenance of giant congenital nevus and melanoma. SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis. The Transcription Factor Encyclopedia. Transcription factor Sox10 orchestrates activity of a neural crest-specific enhancer in the vicinity of its gene.
	2011 Impaired spleen formation perturbs morphogenesis of the gastric lobe of the pancreas Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT. Lack of Wdr36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro. Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer. SOX after SOX: SOXession regulates neurogenesis. SOX9 controls epithelial branching by activating RET effector genes during kidney development. Sox10 is required for Schwann-cell homeostasis and myelin maintenance in the adult peripheral nerve. Sox11 regulates survival and axonal growth of embryonic sensory neurons. Transforming Growth Factor β-Mediated Sox10 Suppression Controls Mesenchymal Progenitor Generation in Neural Crest Stem Cells.
	2010 Activation of Krox20 gene expression by Sox10 in myelinating Schwann cells. All purpose SOX: The many roles of Sox proteins in gene expression. Disruption of ST5 is associated with mental retardation and multiple congenital anomalies. Evolutionary conserved sequence elements with embryonic enhancer activity in the vicinity of the mammalian Sox8 gene. Fusogenic syncytin-1 and transcription factor glial cells missing-a: Presumed regulators in human placental physiology and pathophysiology Glial but not neuronal development in the cochleo-vestibular ganglion requires Sox10. Heterozygous SOX9 mutations allowing for residual DNA-binding and transcriptional activation lead to the acampomelic variant of Campomelic Dysplasia. Identification of Erbin interlinking MuSK and ErbB2 and its impact on acetylcholine receptor aggregation at the neuromuscular junction Identification of Erbin interlinking MuSK and ErbB2 and its impact on acetylcholine receptor aggregation at the neuromuscular junction. In vitro and in vivo effects on neural crest stem cell differentiation by conditional activation of Runx1 short isoform and its effect on neuropathic pain behaviour. L1cam acts as a modifier gene during enteric nervous system development. Organogenesis relies on Sox4, Sox11, and Sox12 for survival of neural and mesenchymal progenitor cells. Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage. Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression. Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system. Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage. SOX10 structure function analysis in the chicken reveals important insights into its role in human neurocristopathies. SoxE function in vertebrate nervous system development. The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development. The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response.
	2009 Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor. Molecular mechanisms of synaptic signal transduction in the healthy and diseased retina Regulation of Boundary Cap Neural Crest Stem Cell Differentiation after Transplantation. Replacement of related POU transcription factors leads to severe defects in mouse forebrain development. Synaptic signal complexes of GABA and Glutamate receptors in the mammalian retina Synaptische Signalkomplexe in der gesunden und erkrankten Retina Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8. The cell-intrinsic requirement of Sox6 for cortical interneuron development.
	2008 A matter of identity: transcriptional control in oligodendro-cytes. Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11. bZIP-type transcription factors CREB and OASIS bind and stimulate the promoter of the mammalian transcription factor GCMa / Gcm1 in trophoblast cells. Differential expression and dynamic changes of murine NEDD9 in progenitor cells of diverse tissues. Examination of transcript amounts and activity of proteinkinase CK2 in muscle lysates of different types of human muscle pathologies. Having it both ways: Sox protein function between conservation and innovation. Identification of integrin-alpha4, Rb1 and syncytin A as murine placental target genes of the transcription factor GCMa / Gcm1 Neural crest origin of perivascular mesenchyme in the adult thymus. PNUTS: A new binding partner of GABA receptors Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody. Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression. SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion. Sox12 deletion in the mouse reveals non-reciprocal redundancy with the related Sox4 and Sox11 transcription factors. SoxE proteins are differentially required in mouse adrenal gland development. The transcription factor Sox5 modulates Sox10 function during melanocyte development.
	2007 Expression of SoxE and SoxD genes in human gliomas. Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages. Induction of oligodendrocyte differentiation by Olig2 and Sox10: evidence for reciprocal interactions and dosage-dependent mechanisms. Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis. Proliferation and Cell-Cell fusion of Endometrial Carcinoma is induced by the Human Endogenous Retroviral Syncytin and regulated by TGF-beta. Prolonged glial expression of Sox4 in the central nervous system leads to architectural cerebellar defects and ataxia. Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system. TNF Pretreatment Interferes with Mitochondrial Apoptosis in the Mouse Liver by A20-Mediated Down-Regulation of Bax. Translation of SOX10 3’ untranslated region causes a complex severe neurocristopathy by generation of a deleterious functional domain.
	2006 A common structural mechanism underlying GCMB mutations that cause hypoparathyroidism. Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction. Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an early embryonic lineage. Expression of Connexin47 in oligodendrocytes is regulated by the Sox10 transcription factor. Identification of developmentally regulated expression of MuSK in astrocytes of the rodent retina. Oligo-dendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas. Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence. Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells. SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. The High-mobility-group domain of Sox proteins interacts with the DNA-binding domains of many transcription factors. The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons.
	2005 From stem cells to neurons and glia: a soxist's view of neural development. GCMB mutation in familial isolated hypo-parathyroidism with residual secretion of parathyroid hormone. GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone. Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect. Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord. Secrets to a healthy Sox life: Lessons for melanocytes. Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions. Syncytin and GCMa, Key regulators in human placental physiology and in pre-eclampsia. The class III POU domain protein Brn-1 can fully replace the related Oct-6 during Schwann cell development and myelination. The high-mobility group transcription factor Sox10 interacts with the N-myc interacting protein Nmi. The high-mobility-group transcription factor Sox8 is a negative regulator of osteoblast differentiation. The POU protein Oct-6 is a nucleocytoplasmic shuttling protein.
	2004 A Sox10 rtTA mouse line for tetracycline-inducible expression of transgenes in neural crest cells and oligodendrocytes. Conservation and variation of structure and function in a newly identified GCM homolog from chicken Conservation and Variation of Structure and Function in a Newly Identified GCM Homolog from Chicken. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Impacts of a new trancription factor family: Mammalian GCM proteins in health and disease. Impacts of a new transcription factor family, Mammalian GCM proteins in health and disease. Interaction, Cooperative Promoter Modulation and Renal Colocalisation of GCMa and Pitx2. Melanocyte-Specific Expression Of Dopachrome Tautomerase Is Dependent On Synergistic Gene Activation By The Sox10 And Mitf Transcription Factors. Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations. Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy.
	2003 A tissue restricted cAMP transcriptional response: SOX10 modulates MSH-triggered expression of MITF in melanocytes. Expression of Sox transcription factors in the developing mouse pancreas. Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia Sox8 is a specific marker for muscle satellite cells and inhibits myogenesis Structural requirements for nuclear localization of GCMa/ Gcm-1. Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Transcriptional activation is a key function encoded by MLL fusion partners
	2002 A recombinant CD7-specific sigle-chain immunotoxin is a potent inducer of apoptosis in acute leukemic T cells Cooperative binding of Sox10 to DNA: requirements and consequences Restricted expression of mouse GCMa/Gcm1 in kidney and thymus Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10 The GCM domain is a Zn-coordinating DNA-binding domain
	2001 Chronicles of a switch hunt: gcm genes in development Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10 Expression of transcription factors during oligodendroglial development Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8 Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling The transcription factor Sox10 is a key regulator of peripheral glial development
	2000 Dual regulation of somatostatin receptor subtype 1 gene expression by pit-1 in anterior pipuitary GH3 cells Electrical activity and postsynapse formation in adult muscle, γ-AChRs are not required. Mol. Electrical activity and postsynapse formation in adult muscle: gamma-AChRs are not required Human cytomegalovirus immediate-early gene 2 expression leads to JCV replication in nonpermissive cells via transcriptional activation of JCV T antigen Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa Protein stability and domain topology determine the transcriptional activity of the mammalian glial cells missing homolog, GCMb Protein zero Gene expression is regulated by the glial transcription factor Sox10 Rab11 is essential for recycling of transferrin to the plasma membrane The glial transcription factor Sox10 binds to DNA both as monomer and dimer with different functional consequences Transcriptional control in myelinating glia: flavors and spices Transcriptional control in myelinating glia: the basic recipe
	1999 A molecular analysis of the Yemenite deaf-blind hypopigmentation syndrome: Sox10 dysfunction causes different neurocristopathies Activation of AP-1 and NF-kappa B transcription factors is involved in hydrogen peroxide-induced apoptopic cell death of oligodendrocytes Bone morphogenetic proteins are required in vivo for the generation of sympathetic neurons Constitutively active MuSK is clustered in the absence of agrin and induces ectopic postsynaptic-like membranes in skeletal muscle fibers Constitutively active MuSK is clustered in the absence of agrin and induces ectopic postsynaptic-like membranes in skeletal muscle fibers. From head to toes: the multiple facets of Sox proteins mGCMa is a murine transcription factor that overrides cell fate decisions in Drosophila The J domain of papovaviral large tumor antigen is required for synergistic interaction with the POU-domain protein Tst-1/Oct6/SCIP
	1998 Absence of polyomavirus JC in glial brain tumors and glioma-derived cell lines Activation of SV40 DNA replication in vivo by amplification-promoting sequences of the mouse ribosomal gene cluster Cooperative function of POU proteins and SOX proteins in glial cells Expression of Sox10 gene during human development Functional analysis of Sox10 mutations found in human Waardenburg-Hirschsprung patients Muscarinic acetylcholine receptors activate expression of the EGr gene family of transcription factors Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter Mutation of the Sry-related Sox10 gene in Dominat megacolon, a mouse model for human Hirschsprung disease Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability. Reconstitution of IL6-inducible differentiation of a myeloid leukemia cell line by activated stat factors Repetitive elements amplified during differential display SOX10 mutations in patients with Waardenburg-Hirschsprung disease Sox10, a novel transcriptional modulator in glial cells Structural requirements for DNA binding of GCM proteins
	1996 Characterization of the Helper Proteins for the Assembly of Tail Fibers of Coliphages T4 and λ.
	1994 Alterations of Receptor Specificities of Coliphages of the T2-Family. Determinants of Receptor Specificity of Coliphages of the T4 Family. A Chaperone Alters the Host Range. Receptor Recognition by T-even Type Coliphages.
	1990 Receptor-recognizing proteins of T-even type bacteriophages. The receptor-recognizing area of proteins 37 of phages T4, TuIa and TuIb.



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